With inhalers
Inhaler Aerosol Generator
The inhaler actuation device is coupled to the PreciseInhale® in order to produce respirable aerosols and precisely dose each exposure object from any inhaler. Suitable for DPIs as well as pMDIs.
Features
- Precise repeatable dosing of exposure object
- Allows coupling of any inhaler to the PreciseInhale®
- (DPIs and MDIs/pMDIs)
- Automatic actuation
- Adjustable inhalation flow rate
- Registration of pressure drop (DPIs)
- USP (United States Pharmacopoeia) design
Benefits
- Enables comparison of formulations in different
- inhalers vs. commercial reference inhaler
- Repetetive and controlled emitted dose
- Actuate any type of inhaler
- In line with development regulation demands
Concentration graph
Technical Specification
| Components | pMDI Trigger (PIINHpt1) |
| pMDI inductor adapter (PIINHpia1) | |
| Inhaler Inductor Tube (PIINHit1) | |
| Inhaler Flow Generator (PIINHfg1) | |
| Critical Orifice (PIINHco1) | |
| Inhaler Flow Pneumotach (PIINHfpne1) | |
| Syringe (PIINHs1) | |
| Measurements: | |
| Additional PreciseInhale® width including inhaler inductor tube and pMDI trigger | 25 cm (left) + 15 cm (right) 1.5 kg |
| Critical orifice | 26 x 15 x 19 cm (W x D x H) (3.2kg) |
| Inhaler flow generator | 41 x 20 x 50 cm (W x D x H) (7.3 kg) |
| Verified exposure modules | Aerosol characterization (DPI and pMDI) |
| DissolvIt ® (DPI and pMDI) | |
| Isolated perfused rat lung (IPL) (pMDI) | |
| Suitable materials | Dry powder inhalers (DPIs) |
| Pressurized metered dose inhalers (pMDIs/MDIs) > 50 different inhalers have been tested | |
| Inhaler flow range | 0 - 116 L/min |
| Actuation time range | 50 - 1 000 ms |
| Pre-pressurization | Yes, for DPIs |
| Pressure drop measurement | Yes, for DPIs in order to verify 4 kPa pressure drop |
| Exposure flow rate | 50 - 500 mL/ min |
| Automatic trigger | Yes, for pMDIs |
| Pressure drop reproducibility | < 10 % standard deviation (n = 180 actuations) Spiriva 18 ?g, inhaler flow rate 38 L/ min, pressure drop 3.9 ± 0.37 kPa, 300 mL aerosol holding chamber, actuation time 300 ms (verified through intra inhaler aerosol generator testing) (IS224) TechSpec Inhaler.pdf Version 1.0 |
