With inhalers

Inhaler Aerosol Generator

The inhaler actuation device is coupled to the PreciseInhale® in order to produce respirable aerosols and precisely dose each exposure object from any inhaler. Suitable for DPIs as well as pMDIs.


  • Precise repeatable dosing of exposure object
  • Allows coupling of any inhaler to the PreciseInhale®
  • (DPIs and MDIs/pMDIs)
  • Automatic actuation
  • Adjustable inhalation flow rate
  • Registration of pressure drop (DPIs)
  • USP (United States Pharmacopoeia) design


  • Enables comparison of formulations in different
  • inhalers vs. commercial reference inhaler
  • Repetetive and controlled emitted dose
  • Actuate any type of inhaler
  • In line with development regulation demands

Concentration graph

Technical Specification

Components pMDI Trigger (PIINHpt1)
pMDI inductor adapter (PIINHpia1)
Inhaler Inductor Tube (PIINHit1)
Inhaler Flow Generator (PIINHfg1)
Critical Orifice (PIINHco1)
Inhaler Flow Pneumotach (PIINHfpne1)
Syringe (PIINHs1)
Additional PreciseInhale® width including inhaler inductor tube and pMDI trigger 25 cm (left) + 15 cm (right) 1.5 kg
Critical orifice 26 x 15 x 19 cm (W x D x H) (3.2kg)
Inhaler flow generator 41 x 20 x 50 cm (W x D x H) (7.3 kg)
Verified exposure modules Aerosol characterization (DPI and pMDI)
DissolvIt ® (DPI and pMDI)
Isolated perfused rat lung (IPL) (pMDI)
Suitable materials Dry powder inhalers (DPIs)
Pressurized metered dose inhalers (pMDIs/MDIs) > 50 different inhalers have been tested
Inhaler flow range 0 - 116 L/min
Actuation time range 50 - 1 000 ms
Pre-pressurization Yes, for DPIs
Pressure drop measurement Yes, for DPIs in order to verify 4 kPa pressure drop
Exposure flow rate 50 - 500 mL/ min
Automatic trigger Yes, for pMDIs
Pressure drop reproducibility < 10 % standard deviation (n = 180 actuations) Spiriva 18 ?g, inhaler flow rate 38 L/ min, pressure drop 3.9 ± 0.37 kPa, 300 mL aerosol holding chamber, actuation time 300 ms (verified through intra inhaler aerosol generator testing) (IS224) TechSpec Inhaler.pdf Version 1.0