With nebulizers
Nebulizer Aerosol Generator
When the Nebulizer Aerosol Generator is mounted to PreciseInhale®, dry powder-like aerosols can be generated from liquid solutions, preferably from ? 1% water soluble starting material. This aerosol can be exposed to either Rat Intratracheal Exposure Module or Rat Nose-Only Exposure Module.
The solution is aerosolized by a modified and integrated nebulizer unit (Aeroneb Pro) and then dried “on the fly” within the holding chamber to a respirable particle size.
Features
- Liquids solutions as starting material
- Real-time and in-line drying
- Optional to deliver either wet or dry-powder-like aerosol from liquid solution starting material
- Monitoring of aerosol concentration during exposure
Benefits
- Dry powder-like aerosol generation of hygroscopic materials or non-micronized powders
- No need of spray drying the material before aerosolization
- Repetitive dose delivery
Concentration graph
Technical specification
| Components | Nebulizer Holder Assembly (PINEBha1) |
| Nebulizer Aerosol Holding Chamber (PINEBhc1) | |
| Nebulizer Unit (PINEBu1) | |
| Nebulizer Unit Support (PINEBus1) | |
| Nebulizer Vacuum Lid (PINEBvl1) | |
| Nebulizer Holding Chamber Lid (PINEBhcl1) | |
| Nebulizer Control Module Holder (PINEBcmh1) | |
| Nebulizer Control Module (PINEBcm1) | |
| Nebulizer Power Cable (PINEBpow1) | |
| Nebulizer Control Module Cable (PINEBcmc1) | |
| Cascade Impactor Metal inserts, 8pcs (PICps1-8x8) | |
| Nebulizer Air Diffuser (PINEBad1) | |
| Air Inlet Tube (PINEBait1) | |
| Air Dryer (glass flask), 2 pcs (PINEBadgf1) | |
| Weight | 3 kg |
| Verified exposure modules | Aerosol Characterization Module |
| Intratracheal Rat Module | |
| Nose-Only Rat Module | |
| Suitable materials | Aqueous solutions |
| Do not use suspensions | |
| Target molecules | ? 1% Water soluble small molecules |
| Neb dosing range | 0.1-10 |
| Exposure time | ? 600 s |
| Exposure flow rate | ? 500 mL/min |
| Drying paper inserts | Disposable, exchange before each new exposure |
| Dose linearity (neb dosing) | R2 > 0.98 (0.5 - 5.0 neb dosing) (verified through intra- and inter neb unit tests) 8% (w/w) NaCl solution (H2O) (30-600 s) |
| Dose linearity (exposure time) | R2 > 0.99 (30 - 600 s) (verified through intra- and inter neb unit tests) 8% (w/w) NaCl solution (H2O), neb dosing 1.0 |
| MMAD (mass median aerodynamic diameter) dependency of neb dosing | Not significant, p = 0.35 (p > 0.05) Neb dosing 2 and 10, imipramine 4% 0.1 X PBS solution, exposure time 300 s, exposure flow rate 440 mL/min |
| MMAD (mass median aerodynamic diameter) dependency of exposure time | Not significant, p = 0.36 (p > 0.05) Exposure time 130, 180 and 300 s, imipramine 4% 0.1 X PBS solution, neb dosing 10, exposure flow rate 170 mL/min |
| Consumables | Drying Paper Inserts, 11x15 cm, packed with silica gel. 10 pcs or 100 pcs/pack (PICNdphc10 or PICNdphc100) Air Dryer Silica Gel, portion-packed, 10 pcs/pack (PICNsgx10) |
